Question
Case AssignmentIn the Module 4 Case assignment you will have the opportunity to explore the new era of personalized medicine that uses genetic mapping to determine medical treatment. Watch the NOVA video:.pbs.org/wgbh/nova/body/cracking-the-code-of-life.html>Cracking Your Genetic Code to learn more about the genetic technology available to us and what it means for medicine, ethics, and the future of human society.After watching this video, proceed to the following resource and address the topics below in a 2-3 page paper.nature.com/scitable/topicpage/genetic-mutation-1127>http://www.nature.com/scitable/topicpage/genetic-mutation-11271. Explain what a genetic mutation is and the difference between inherited mutations versus point mutations.2. Describe how the technology explained in Cracking Your Genetic Code can be used to detect mutations and predict your health.3. Form an opinion on whether or not you support utilizing genetic mapping to develop personalized medical treatment. Find evidence to support your opinion and cite your sources. What dangers do you see dangers in knowing our personal genome?Assignment ExpectationsThis paper should be approximately 2-3 pages long and reflect the information contained in the resources provided above. When summarizing the information you read from the Nature website, NOVA video, or any resources you use to support your opinions, be sure to synthesize the information into your own words, and cite the references. Please use complete sentences and write your paper in essay format using subheadings to organize the required topics.Module 4 SLP
GENETICS AND HEREDITYOverview
For the Module 4 SLP, you will build on your understanding of the structure of DNA, genetics, and inheritance by exploring some applied genetic engineering techniques. You will review the three papers you have read on the Deepwater Horizon Spill:Biello D (2010).trident.edu/d2l/common/dialogs/quickLink/quickLink.d2l?ou=53245&type=content&rCode=TUI-48087>Clean Up the Deepwater Horizon Oil Spill. Scientific America: May 25, 2010.Urakawa, H., Garcia, Juan C., Barreto, Patricia D., Molina, Gabriela A., Barreto, Jose C. (2012)..trident.edu/d2l/common/dialogs/quickLink/quickLink.d2l?ou=53245&type=content&rCode=TUI-48086>A sensitive crude oil bioassay indicates that oil spills potentially induce a change of major nitrifying prokaryotes from the Archaea to the Bacteria.Environmental Pollution. 164:42-45Byrd D (2014).trident.edu/d2l/common/dialogs/quickLink/quickLink.d2l?ou=53245&type=content&rCode=TUI-48090>How oil spill chemicals cause heart failure in fish.EarthSky Feb 18, 2014.and consider the effects of toxicity on representative members from three domains:Archaea -Nitrosopumilus maritimusBacteria -Nitrosococcus oceaniEukarya -Thunnus thynnus(Atlantic Bluefin Tuna)In order to make connections between the results found in these studies, assess the damage caused by the Deepwater Horizon Oil Spill and move forward in your analysis on how best to remediate the spill.After analyzing these studies in various assignments in the previous modules, you will now prepare a document for your Shoreline Assessment Team that describes your first interpretation of the data and discusses one approach to remediation that involves genetic engineering.View these resources to complete this assignment:Scientific American Instant Egghead Video: Can Microbes clean Up Our Oily Mess?.scientificamerican.com/video/can-microbes-clean-up-our-oily-mess2013-12-11/>http://www.scientificamerican.com/video/can-microbes-clean-up-our-oily-mess2013-12-11/Interview with Professor Barbara Block on BBC News:.bbc.co.uk/news/science-environment-26184116>http://www.bbc.co.uk/news/science-environment-26184116Tutorials on Genetic EngineeringMaking a Recombinant Plasmid
.unl.edu/pages/animation.php?a=making_a_recombinant_plasmid.swf&b=1003514583>http://plantandsoil.unl.edu/pages/animation.php?a=making_a_recombinant_plasmid.swf&b=1003514583Bacteria Transformation.unl.edu/pages/animation.php?a=Bacteria_Transformation.swf&b=1003514686>http://plantandsoil.unl.edu/pages/animation.php?a=Bacteria_Transformation.swf&b=1003514686AssignmentPrepare a 3-4 page document that outlines your analysis of the effects of the Deepwater Spill on study species in the Gulf of Mexico. In your report include:Part I Influence of Crude Oil onNitrosopumilus maritimusandNitrosococcus oceani1. Which species appeared to be affected by crude oil assays in the Urakawa et al (2012) study? How were they affected in the study?2. Based on what you know about the metabolism of the organisms, which species was more likely to have been successful in an environment with abundant hydrocarbons?Part II Influence of Crude Oil onThunnus thynnus(Atlantic Bluefin Tuna)1. Provide an overview of the documented effects of crude oil onThunnus thynnus.2. What stage of development is affected and how could this affect the population?3. What economic impact would this have on the area?4. What is a highly conserved gene? What relationship do these results have to the effects of hydrocarbons on humans?Part III Recommendations for RemediationDo you recommend genetically engineering a prokaryote to remediate this spill? In your assessment provide reasons for BOTH why and why not this would be a good approach, and describe which genes would need to be targeted and which species would be better suited to be transformed -Nitrosopumilus maritimusorNitrosococcus oceani.SLP Assignment Expectations
The Session Long Project consists of an integrative project emphasizing the personalized application of each modules concepts. For Modules 15, students are required to engage in an original integrative project reflecting their comprehensive knowledge of and ability to apply the course materials. Each component of the SLP will be graded on a modular basis.Your essay is considered a scholarly work. You will be provided with many scholarly references to begin each assignment. For any additional research you are required to do to complete your assignment, please use scholarly references such as a peer reviewed journal article or a government sponsored or university sponsored website. As you read through your sources, take notes from your sources and then write your paper in your own words, describing what you have learned from your research. Direct quotes should be limited and must be designated by quotation marks. Paraphrased ideas must give credit to the original author, for example (Murray, 2014). Direct copying from homework help websites will not receive credit.When you write your essay, please organize your paper to include an introduction (overview of the assignment), body with subtitles (reflecting the requirements of the assignment), and a summary (develop connections between the required topics).