How might second mutation lead to restoration of activity
Pepsin-a protelytic enzyme-cleaves the heavy chains
August 4, 2017Solution-How can you prevent or slow down the spread
August 4, 20171) A mutation that changes an alanine residue in the interior of a protein to valine is found to lead a loss of activity. However, activity is regained when a second mutation at different position changes an isoleucine residue to glycine. How might this second mutation lead to restoration of activity?
2) Identify the functional groups in side chain of a protein that can form hydrogen bonds or electrostatic interactions with a side chain of arginine within the same protein with pH of 7.0.
