Q1. Johnny fractured lower third of his right tibia in a skiing accident. The soft tissues in the area were severely damaged and their surgical removal was necessary. After prolonged immobilization, it was found that Johnny was healing extremely poorly. Why did Johnny have poor healing?

Q2. Assume you have engineered a set of genes, each encoding a protein with a pair of conflicting signal sequences that specify different compartments. If the genes were expressed in the cell, predict that signal would win out for the following combinations. Give details your reasoning.