What will be the equilibrium frequency
Determine the location of the his mutation
August 4, 2017Determine whether the procedure falls within the rn scope
August 4, 2017The gene for sickle-cell anemia exhibits heterozygote advantage. An individual who is an HB-A/HB-s heterozygote has increased resistance to malaria and therefore has greater fitness than the HB-A/HB-A homozygote, who is susceptivle to malaria, and the HB_S/HB-S, who has sickle cell.
A) Suppose that the fitness values of the genotypes are. HB-A/HB-A=.88, HB-A/HB-S=1.0, and HB-S/HB-S=.14. Give the expected equilibrium frequencies of the HB-S gene?
B) Suppose malaria is virtually eradicated and the heterozygote advantage becomes HB-A/HB-A=.99, HB-A/HB-S=1.0, and HB-S/HB-S=.14. What will be the equilibrium frequency of HB-S/HB-S?
