Based on the readings, what is one problem / challenge facing the newly established American Empire?

Link to the readings:
https://uerjundergradslit.files.wordpress.com/2020/09/the-norton-anthology-of-american-literature-9th-edition-volumes-a-b.pdf

5 readings:
Las Casas, Columbus Letter of Discovery,
Franklin The Way to Wealth, &
Rules by Which a Great Empire,
Sewall The Selling of Joseph,
Mather A People of God in the Devils Territories,
Cherokee Women To Governor Benjamin Franklin