How would the 2-flouro substitution prevent cleavage
Solution-Better name for communicating with non-scientific
August 4, 2017Direction depending on the needs of the animal
August 4, 2017Many groups are using modified RNA with 2′-deoxy-2′-fluoro substitutions for riboses (i.e. a 2′-fluorine instead of a 2′-OH) to prevent RNA cleavage by ribonucleases.
How would the 2′-flouro substitution prevent cleavage of the phosphodiester bond by ribonucleases?
