Which did the most to refute the concept of vitalism

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Which did the most to refute the concept of vitalism

Q1. The concept of vitalism is based on the belief in a life force outside the jurisdiction of physical and chemical laws. According to this belief, organic compounds are able to arise only within living organisms. Which did the most to refute the concept of vitalism?

Q2. The endocrine and nervous systems are major regulating systems of the body. Though, the nervous system has been compared to an airmail delivery system and the endorcrine system to the pony express. In brief explain this comparison.

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